Hollow-Fiber Liquid-Phase Micro-Extraction Method for the Simultaneous Derivatization, Extraction, and Pre-concentration of Organotin Compounds from Packed Fruit Juices

Abstract Organotin compounds are widely employed as pesticides and fungicides in agriculture stabilizers for the industrial manufacture of polyvinyl chloride other polymers. Accordingly, these endocrine disruptors can be found a variety foods beverages. In present study, we describe optimization hollow-fiber liquid-phase micro-extraction approach simultaneous derivatization, extraction, pre-concentration butyltin species from commercial fruit juices with aim investigating their migration packaging. The best extraction efficiencies were achieved by using hexane acceptor solvent polypropylene fiber length 2 cm, whereas agitation speed, temperature, total time set at 1100 rpm, 25 ºC, 10 min, respectively. Using optimal conditions, method was satisfactorily validated terms linearity (5–1000 µg L −1 ), limits detection (0.8–1.8 recovery (80.5–92.1%), intraday precision (10.2–13.1%), inter-day (11.0–15.5%), matrix effect (83.2–91.8%), accuracy (85.2–95.2%), specificity, carryover. application this technique to samples obtained local market demonstrated that levels organotin packed negligible, agreement established European Food Safety Authority (0.14 mg per kg food).